It’s been a while since I discussed medical marijuana, even though
it’s a topic I’ve been meaning to come back to since I first dubbed
medical marijuana to be the equivalent of herbalism and discussed how the potential of cannabinoids to treat cancer has been, thus far, unimpressive, with relatively modest antitumor effects.
The reason I refer to medical marijuana as the “new herbalism” is
because the arguments made in favor of medical marijuana are very much
like arguments for herbalism, including arguments that using the natural
plant is superior to using specific purified cannabinoids, appeals to
how “natural” marijuana is, and claims of incredible effectiveness
against all manner of diseases, including deadly diseases like cancer,
based on anecdotes and testimonials.
Now, as I pointed out before, not
only am I not opposed to the legalization and regulation of marijuana
for recreational use, even though I’ve never tried it myself, but I support it.
What I do not support are claims for medical effects that are not
backed up with good scientific evidence, and for medical marijuana most
claims fall into that category. That’s why I tend to view medical
marijuana as a backdoor way to get marijuana legalized. Personally I’d
rather advocates of marijuana legalization drop the charade, argue for
legalization, and stop with the medical nonsense.
The last time around, I discussed the evidence
supporting claims that “cannabis cures cancer” and found them to be
wanting based on science. I didn’t however, discuss the “cannabis cures
cancer” testimonial machine that drives the claim that marijuana is
useful for treating cancer; at least, I only touched on it by discussing
briefly Rick Simpson, who claims that his hash oil cures approximately 70% of patients with terminal cancer
and a published anecdote in which it was claimed that hemp oil was
effective in treating acute lymphoblastic leukemia.
(It wasn’t. At
least, the evidence presented was not convincing.) Since then, I’ve
wanted to revisit the topic of “cannabis cures cancer” testimonials,
and, for whatever reason, now seems like a good time to do it, not the
least of which because there was recently a BBC news report by Alastair Leithead
that presented a desperate patient with stage IV presenting cannabis as
her last hope for survival. It also featured a cancer patient by the
name of Stefanie LaRue who claimed that cannabis had been highly
effective against her stage IV breast cancer, even going so far as to
add an additional claim, namely that she used only cannabis, no
chemotherapy. In this, the news story was horrible and highly
misleading, because LaRue’s story, as you will see, is far more complex
than what is presented, and while it’s true that LaRue hasn’t had any
chemotherapy in the relevant timeframe, that does not mean she did not
receive conventional treatment, as you will see.
Stefanie LaRue
AFter seeing Leithead’s story, I decided to look into the “cannabis cures cancer” testimonial of Stefanie LaRue.
Hers is a sad story in that she was diagnosed at a young age (30 years
old) after her boyfriend found a lump in her breast and misdiagnoses by
three different doctors. In many ways, her story
is an inspiring one based on her will to fight and her activism, which
have led her to have served on the Board of Directors for the Los
Angeles Susan G. Komen for the Cure, Southern California’s Breast Cancer
Network of Strength, and the USC Norris Cancer Center’s Cancer
Survivorship Advisory Council. Near and dear to my heart, she also is
very much into rescuing and fostering many wounded, mistreated and
special needs dogs.
Indeed, I approach this particular testimonial with
more than a little trepidation because there’s an incredible amount to
admire about LaRue and, more importantly, her involvement with Komen and
other breast cancer charities means that people I respect and admire
(who might read this) very well might know her—or even be friends with
her. Still, given the direction her story has taken, I feel obligated to
discuss it.
Here’s a video of her from 2007 when she was still undergoing chemotherapy:
Notice the themes we see so often in cancer patients, particularly young cancer patients:
Why me? There
must
be a reason. It can’t have “just happened”.
Breast cancer is a disease
of older women. (Indeed, the mean age at diagnosis is around 61.) There
must have been something in the environment. Possibly. As has been discussed before,
for breast cancer, environment- and lifestyle-attributable causes
account for a much smaller fraction of cancer diagnoses than most people
believe, and 1.8% of cases of breast cancer occur in women 34 and under. Given that there are approximately 233,000 new cases of breast cancer
diagnosed every year in the U.S., that means that close to 4,200 women
under 34 are diagnosed each year with breast cancer. Still, being
diagnosed with breast cancer at age 30 is unusual; so it’s
understandable that LaRue would wonder why it happened to her.
Worse, LaRue was diagnosed with Stage IV disease, as described in an article by Sonja Renea published on the
Medical Jane website entitled “Meet Stefanie LaRue: Cancer Survivor and Medical Marijuana Advocate“:
Stefanie was sent home several times with several rounds
of antibiotics, which is quite telling of younger folks being
misdiagnosed. By the time she could be tested thoroughly, the cancer had
spread to her bones. Doctors diagnosed her with Stage 4 Metastatic
Breast Cancer, which is cancer that has spread beyond the breast to
other organs in the body. The prognosis was grim: she was given a year
to live, at most.
Three weeks later, Stefanie began her first round of chemotherapy. To make matters worse, she had to to [sic]
cope with her employer, who showed little sympathy for her situation.
Despite her job in commercial real estate being very stressful, she was
expected to work through her cancer treatment.
This is a big problem with health care in the U.S. besides the
difficulty many people have affording health insurance, a problem only
partially alleviated by the Affordable Care Act (a.k.a. Obamacare),
which didn’t exist in 2005. You can be diagnosed with metastatic breast
cancer and still be screwed as far as work goes. It happens far too
often in this country.
So LaRue ended up quitting her job and filing for disability. She
underwent six rounds of chemotherapy and then a mastectomy.
At this
point reading her story I had a question. If LaRue had bone metastases,
it’s not clear to me why her surgeon and oncologist would recommend that
she undergo a mastectomy. Three possible reasons suggest themselves to
me as a breast surgeon. One is that it was done to prevent the primary
tumor from growing through the skin and turning into
en cuirasse disease,
although usually such surgery is not done right after chemotherapy but
when the tumor has started to grow again. Another is that she had a
complete radiologic response to the chemotherapy, meaning that all her
breast and bone disease disappeared.
When that happens and the patient
has been rendered “no evaluable disease” (NED), we will often treat her
as though she were not stage IV and undertake surgery with curative
intent. The final possibility is that surgery was done with the intent
of prolonging survival even though metastases were still present. It’s
been an ongoing controversy in breast cancer over whether removing the
primary tumor prolongs survival in stage IV disease or whether the
apparent improvement in survival due to surgery is due to selection
bias; that is, bias towards healthier patients with less aggressive
disease who are chosen to undergo surgery preferentially.
More recent
evidence suggests that removing the primary probably doesn’t improve
survival, but that was not at all clear back in 2005. (To be honest, it
still isn’t quite clear.)
On her website, LaRue reports
that her tumor was 8 cm in diameter (which is big). Apparently her
tumor didn’t shrink enough to be removed in a lumpectomy; so she needed a
mastectomy:
After chemo she had surgery to remove the cancer. But her
margins were not clear, so another surgery followed. She was left with
only skin and a nipple on the right side of her chest. Her breast
surgeon had scraped all the way down to the chest wall removing all the
breast tissue possible but sparing the skin. Despite the advanced stage
of her cancer, she got to keep the outside of her breast because she had
a skin-sparing mastectomy. A plastic surgeon was later able to
reconstruct her breast, restoring her shape, her femininity and her
sexuality.
At this point in my reading, I was unclear as to why a surgeon would
do a skin-sparing mastectomy in a patient with stage IV disease. Most
plastic surgeons are reluctant to do reconstruction in such a patient
because reconstruction can be a big operation, and if the patient isn’t
expected to live more than a year it just doesn’t make a lot of sense to
have the patient spend a significant chunk of her remaining time
recovering from surgery, having additional surgeries to “touch up” the
reconstruction.
The willingness of her surgeon and plastic surgeon to
undertake a skin sparing mastectomy and reconstruction suggests to me
that she had a very good response to the chemotherapy and/or that her
prognosis as a stage IV patient was viewed as being considerably more
favorable than usual.
Whatever the case, during the chemotherapy that she underwent before
her surgery, LaRue looked to alternative medicine to ease her symptoms:
She found help with an integrative oncologist at UCLA,
where she learned how to make changes to her diet, use natural
supplements, get acupuncture, and work on personal fitness; all of which
are integrative, complementary, and alternative treatments to go along
with chemotherapy.
Now here’s the thing. As a patient with stage IV disease, LaRue did
really
well for eight years. It’s hard to find a good detailed description of
what happened between November 2005 (when she was diagnosed with breast
cancer) and 2013, but she didn’t start using cannabis oil until 2013,
which means that conventional oncology is what got her through nearly
eight out of the nine and a half years she’s survived with her stage IV
cancer.
It’s important to remember that when looking at a lot of the
articles about LaRue, because before 2013, although she had gone all in
for “integrative oncology,” she hadn’t yet discovered cannabis and was
still being treated with mostly conventional medicine. So, between 2006,
when she finished her initial treatment, and at least September 2013,
when she posted a series of images to Instagram of her hospitalization for thoracoscopic surgery, conventional medicine is what kept LaRue alive.
So when Sonja Renea of the
Medical Jane website
writes that “Stefanie LaRue was 30 years old when she was diagnosed
with Stage 4 Metastatic Breast Cancer and given the dismal prognosis of
less than a year to live” and follows it up with, “That was nine years
ago,” she is being deceptive.
This is how it’s described in the
Medical Jane:
In 2013 Stefanie had a Video-Assisted Thoracoscopic
Surgery (VATS) and the results were not good. This was now her third
reoccurrence of cancer. The chemo sensitivity testing concluded there
were five lines of chemo treatments that would work on the tumors.
Stefanie declined the treatment. “I did my homework. I researched as
much as I could. I watched. I listened. I read. I contacted. I prayed.
Most of all, I believed. I weighed my options, which were essentially
chemotherapy or cannabis oil, and I decided to take the natural route
this time…” she says.
Stefanie followed the Rick Simpson Oil (RSO) protocol until she was
cancer-free. “Cannabis oil killed all of the tumors in my body. My
monthly lab and quarterly scan results are proof that the cannabis oil
treatment worked,” she says. Her doctor, who had previously been
skeptical, now credits these “alternative” treatments as the reason for
her speedy recovery.
On Instagram, LaRue described it thusly in a posting dated October 2, 2013:
Dear cancer, as we both know, yesterday was a big day of
news. And sadly for you, you lost. You lost your “upper hand” you tried
to claim in that you were potentially showing up again (unwelcomed in my
body) not as a metastatic reoccurrence, but as a possible new primary
cancer. Which would have been a much more challenging ass kickin match
between you and I. None the less, I would have enjoyed. But since you
are now known as the same initial metastatic breast cancer reoccurring, I
hope you are preparing for what is coming to you.
Because now I have
the upper hand. When the chemo sensitivity tests are complete on my
biopsy tissue at Caris Labs we will know exactly what to come after you
and all your little friends with! Poor you. I know your still cowardly
hiding in my body but you have pissed off some pretty important people
that care a lot about me and guess what… Now they too are coming in to
whip your ass!!!
We’ve encountered Caris Labs before in the context of discussing Stanislaw Burzynski’s incompetent “personalized gene-targeted cancer therapy.”
Basically, Caris is a company that will do various genomic tests and
immunohistochemistry on a tumor sample to try to identify which targeted
agents it might be sensitive to. I’ve basically discussed how the
routine use of such a test is premature, given that there isn’t any good
evidence that using a test like the one from Caris or other competing
tests results in better response rates or prolonged survival, but such
tests have still proliferated and their use is not uncommon, even in
academic medical centers.
In any case, at this point in the fall of 2013, LaRue was facing her
third recurrence of cancer. Unfortunately, this is a story very much
like the many alternative cancer cure testimonials I’ve deconstructed
over the years in that we lack a lot of key information, which means
that I can only speculate. First, we don’t know how extensive a cancer
recurrence LaRue had. Given that she underwent thoracoscopic lung
surgery (a thoracoscope is like a laparoscope, except that instead of
letting a surgeon operate in the abdomen it allows the thoracic surgeon
to operate in the chest with minimal incisions), presumably she had a
lung nodule.
In a patient with stage IV disease, most such lesions would
be biopsied using a core needle under CT scan guidance, rather than
excised surgically through a laparoscope. Why did the surgeon choose
this course?
A couple of possible reasons suggest themselves from the story.
First, perhaps she did undergo a CT-guided core needle biopsy and the
diagnosis was uncertain. Certainly LaRue’s Instagram posting, in which
she gloats over her tumor for not being a new primary tumor but just the
same as the other recurrences of her original tumor, suggests that this
could be the case.
After all, a new suspicious lung nodule in a breast
cancer patient is usually considered a new metastasis until proven
otherwise. In any case, in patients with metastatic disease, a tissue
diagnosis is always imperative before beginning treatment if at all
feasible. Another possibility is that this tumor, whatever doctors
thought it was before surgery, was the only site of disease detectable.
In such a case, particularly in a young patient who had been doing well
for nearly eight years even if she did have stage IV disease, strong consideration would be given for excising the cancer
and eliminating the only known site of disease even though the evidence
that metastasectomy (removing the metastasis) will prolong survival in
breast cancer is mostly without controls
and thus prone to selection bias.
(Metastasectomy of liver and lung
metastases can definitely prolong survival in colorectal cancer.) Still,
there is evidence that in select patients removing pulmonary metastases
can result in significant survival benefit. Whether LaRue is one of
those select patients is unclear.
So here’s what I think probably happened. After surgery LaRue
(understandably) did not want to undergo further chemotherapy. For
whatever reason, she latched on to Rick Simpson’s hemp oil
as the treatment that would control her cancer.
How she found out about
it and why she became convinced it would cure her, it’s hard to say
from publicly available information. In the
Medical Jane
story, LaRue proclaims that “cannabis oil killed all the tumors in my
body” and that her “monthly lab and quarterly scan results are proof
that the cannabis oil treatment worked.” It is, of course, impossible to
confirm or dispute this assessment without knowing what all her scans
showed.
There is, however, a photo on Instagram of LaRue receiving a shot, which she identifies as Xgeva, which LaRue described as “bone mets maintenance.” And so it is.
It’s a monoclonal antibody against the RANK ligand, a protein that acts
as the primary signal for bone removal, and it prevents fractures in
patients with bone metastases. So this implies that LaRue still has bone
metastases. It also makes one wonder what other non-chemotherapy
conventional therapy she might be taking. There’s also a post by her on
Twitter asking about Afinitor (everolimus):
Afinitor is a drug that inhibits an enzyme called mTOR and is used in
cancer that is positive for the estrogen receptor after it develops
resistance to anti-estrogen therapy. Apparently she did not take
Afinitor, because on March 14, 2014 LaRue posted a photo on Twitter:
In the photo, LaRue is receiving an injection of Zoladex (goserelin),
a drug used to suppress production of sex hormones. In other words, six
months after her thoracoscopy, LaRue was receiving conventional medical
therapy, specifically a treatment to shut down her ovaries’ production
of estrogen.
Thus, LaRue appears to be the case of a cancer patient who
chose unproven alternative medicine but at the same time continued to
receive conventional medical therapy for her cancer and did very well.
As is the case with most such patients, she attributes her excellent
outcome, at least after her most recent relapse, far more to the
alternative treatments (in this case, Rick Simpson’s hemp oil) than she
does to the conventional therapy she is also taking, even after her
discovery of hemp oil.
I also can’t help but point out that the very
fact that LaRue survived nearly eight years with stage IV cancer before
discovering hemp oil is a pretty strong argument that from a biological
standpoint her tumor is pretty indolent, as some tumors positive for the
estrogen receptor are; so it’s not surprising that she would still be
alive a year and a half after her thoracoscopy on Zoladex and Xgeva
alone (plus whatever other conventional medical therapy she is
receiving). Only LaRue and her oncologist know for sure, though, and her
oncologist can’t tell anyone without her permission.
Finally, there’s the claim that LaRue is now cancer-free, without
having undergone chemotherapy this time around, a claim repeated in Leithead’s credulous interview.
There’s even a brief scene showning a radiology report, which, if you
freeze frame, indicates that there are still lesions in her spine that
could be consistent with healing metastases, but there are no new ones.
What does this mean? Who knows? Without her full clinical history and
full knowledge of what she is taking in addition to the cannabis, it’s
impossible to tell.
Cannabis versus breast cancer
As much as I admire the grace and determination with which Stefanie
LaRue has endured over 9 years after her cancer diagnosis, as a cancer
doctor it bothers me profoundly that she has allowed herself to fall
under the spell of the “cannabis cures cancer” alternative medicine
crowd, in particular Rick Simpson. I discussed Simpson the last time I wrote about cannabis and cancer.
As I said at the time, Rick Simpson is just like cancer quacks the
world over, who have no firm evidence to back up their
miraculous-sounding cure rates and excuse their failures by blaming the
treatment patients had before they started the quackery.
Quacks like
Rick Simpson do those who think that cannabinoids have promise in
treating cancer no favors.
I also discussed how the vast majority of studies touted by the
“cannabis cures cancer” advocates tend to be preclinical studies in cell
culture or animal models that show relatively modest antitumor effects
due to various cannabinoids. Indeed, this article on
Medical Jane, “Studies Show Cannabinoids May Help Fight Triple-Negative Breast Cancer“,
fails to provide particularly convincing evidence that they do.
Before I
look at the studies, I can’t help but note that triple negative breast
cancer is breast cancer that makes neither the estrogen receptor (ER),
the progesterone receptor (PR), nor overexpressed HER2. Yet the article
invokes Stefanie LaRue, who clearly has ER(+) breast cancer.
Another thing that needs to be pointed out. Every single one of the studies invoked by
Medical Jane
has nothing to do with hemp oil, be it Rick Simpson’s hemp oil or some
other type.
Each of the studies examines either purified cannabinoids
or, in the case of this study, a chemically modified cannabinoid. This study cited in
Molecular Cancer,
for instance, looks Δ9-tetrahydrocannabinol, the most abundant and
potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2
receptor-selective agonist. Both inhibit the growth of HER2(+) breast
cancer cells in cell culture and in mice, but the concentrations needed
are pretty high, with an IC50 (concentration that is 50% of maximum
inhibition) in the range of 5 to 10 μM, concentrations achievable with
injection of purified compound but certainly not by smoking pot
You are also unlikely to achieve these levels by drinking hemp oil, which, by the way, usually contains so little THC
that it is below the limit of detection for common assays and
manufacturers brag that it’s impossible to fail a drug test if you’re
consuming hemp seed oil because “THC levels in our products are barely
measurable.” Of course, I do realize that Rick Simpson calls his oil
hemp oil even though it’s really cannabis oil derived from the buds
rather than the seeds, but even he brags
that “following the dosage previously described, many people can take
the full treatment and never get high,” which implies that his oil
achieves nowhere near the concentration of THC in the blood necessary to
be active against cancer.
Moreover, oral bioavailability of THC from
such oils is notoriously low,
between 4-20%, making it unlikely that concentrations well above the 10
μM necessary to inhibit or kill more than 50% of the cancer cells are
achievable with oral dosing.
Thus, the various studies cited, such as this one, which shows inhibition of the epidermal growth factor pathway by purified cannabidiol (CBD), a non-psychotropic cannabinoid; this one, the aforementioned study that examines purified Δ
9-THC
and JWH-133 against HER2(+) breast cancer; and this one, which also
examines CBD in breast cancer, are interesting and very preliminary.
Moreover, they all examine cannabinoids purified from cannabis, and one
even examines a chemically modified cannabinoid. In other words, even if
cannabinoids make the jump from preclinical models to humans, these
studies do not support the use of medical marijuana, either smoked as
the plant or ingested as an oil, to treat breast cancer. They also do
not suggest sufficient activity to produce miracle cures of stage IV
cancer as described by Rick Simpson.
Indeed, a recent review concludes that “current preclinical data does not yet provide robust evidence that systemically administered Δ
9-THC will be useful for the curative treatment of cancer,” although CBD might have a role based on preclinical data.
Neither cannabinoid, however, is likely to be curative for advanced
cancer. It’s possible that specific cannabinoids might have a role to
play in the multimodality treatment of cancer, but, given what we know
about them from preclinical studies, it’s highly unlikely that
cannabinoids, medical marijuana, or Rick Simpson’s hemp oil can cure
stage IV cancer of any kind.
Hope versus hype
I have no doubt that Stefanie LaRue honestly believes that Rick
Simpson’s hemp oil is the reason why she’s still alive today and doing
so well. I can’t help but point out that Stanislaw Burzynski’s patients,
for example, also honestly believe that his antineoplastons are what
saved their lives, even though even Burzynski can’t produce good
evidence that they have antitumor activity. Depressingly, it just goes
to show how even such an accomplished woman can fall prey to the same
human cognitive shortcomings that we all share and confuse correlation
with causation.
If it were just her, I wouldn’t have felt obligated to
write this post, but LaRue makes it very clear that not only does she
believe that Rick Simpson’s hemp oil allowed her to heal herself of her
longstanding metastatic cancer:
But she plans on becoming an evangelist for Rick Simpson’s hemp oil and medical marijuana:
In this video she notes that she’s had multiple recurrences and
they’re all gone, after which she challenges the viewer to “explain
that.” Believe it or not, personally, I’d be overjoyed if something as
simple as hemp oil could treat stage IV cancer so effectively. I really
would, as it would mean that I’d rarely have to see a breast cancer
patient die.
However, although I can’t be sure without a lot more
information (which is highly unlikely to be forthcoming) and I do have
to concede the possibility, albeit remote, that Rick Simpson’s hemp oil
is the reason why LaRue has survived a year and a half since her last
new metastasis, I nonetheless suspect that it is far more likely than
not that it is the Zoladex and the Xgeva (not to mention whatever other
conventional treatments that LaRue may be taking that she hasn’t
mentioned on social media) that are keeping her going now, combined with
her disease’s already-demonstrated indolent biology.
And long may they continue to do so!
For nearly eight years, Stefanie LaRue fought a battle with courage,
inspiring intelligence, and grace. Her story was (and still is) a story
of hope for women with stage IV cancer that they can live a long time
with the disease with good quality of life. Unfortunately, a year and a
half ago her story took a turn into pseudoscience, becoming a cautionary
tale of how even the most intelligent, ambitious, and determined person
can be subject to magical thinking.
This would not be an issue with me
were it not that, inadvertently, and with the best of intentions, LaRue
has declared her determination to promote Rick Simpson’s hemp oil as a
cancer cure, using her own story as an example of what it can do. Given
her proven history of advocacy and her numerous accomplishments with
organizations like the Komen Los Angeles County Affiliate from 2008 to 2010
(before she discovered hemp oil), I can’t help but be worried that she
will in her quest to save women from stage IV breast cancer end up doing
exactly the opposite for some women.
I still hold out hope that, given her history, LaRue will eventually
realize that her true story is far more a cause for hope for women with
stage IV disease than her current belief that cannabis is what has kept
her alive.. Thanks to advances in breast cancer care, more and more
women with stage IV disease are living a lot longer than expected, even
ten years, all with no need to resort to unproven treatments promoted
with testimonials, like Rick Simpson’s hemp oil.
That’s the
real reason for hope.